Electrical Stimulation-Mediated Differentiation of Neural Cells on Conductive Carbon Nanofiller-Based Scaffold

An important strategy in neural tissue engineering involves imparting electrical properties to the regenerative template encourage cell proliferation and differentiation. Several clinical studies have confirmed that direct or indirect stimulation therapy greatly impacts treatment of peripheral central nerve injury. Nerve regeneration can be accelerated by application stimulations different methods with varying parameters. For a long period, along conventional conductive polymers played an role regeneration, due their conductivity. However, low biocompatibility these materials has brought attention toward need for alternative polymers. Carbon nanofillers (graphene, nanotubes, derivatives) been showing promising results bioimaging, biosensing, composites, simultaneously, proving themselves as prospective biomaterial repair excellent mechanical properties, alongside, biocompatibility. Therefore, carbon nanofiller-based scaffolds synchronized may lead breakthrough This review article focuses on influence carbon-based material engineering. In this article, we explicitly focus deliver pathways involved differentiation neuronal cells. Emphasis is given analysis suitable fabrication strategies scaffold way its interfaces interact neurons promoting Furthermore, summarizes ongoing advancements augment conductivity biological activities (cell adhesion, proliferation, differentiation, neurite outgrowth), well reduce potential toxicity scaffolds.